FINAL UPDATE: SARS-CoV2 PROPHYLAXIS FOR THE GENERAL POPULATION
Abstract
Presenting to the World Medical Community, the incontrovertible validation of the outlandish notion that there could be a simple, safe, and inexpensive solution to the SARS-CoV-2 Pandemia provided by non-other than Mother Nature.
SARS-CoV2 PROPHYLAXIS FOR THE GENERAL POPULATION was introduced on 29 NOVEMBER 2020 to the consciousness of the international medical community. Since then, 39,782 prescient physicians explored the proposed solution and 2,754 experienced doctors downloaded it.
In the document, it was stressed external and internal (oral) measures. All should use products containing the surfactant Sodium Lauryl Ether Sulfate or Sodium Laureth Sulfate, take Zinc Gluconate, Citrate or Picolinate and Vitamins D3 and C in weight and age-appropriate doses. Since the actions of Vitamin C are well known, the rationale for the use of Zinc and Vitamin D3 were presented:
1. Zinc is essential for the function of the immune system. Zinc ions are involved in regulating intracellular signaling pathways in innate and adaptive immune cells. Zinc homeostasis is largely controlled via the expression and action of Zinc Importers (ZIP 1–14), Zinc Exporters (ZnT 1–10), and zinc-binding proteins. Anti-inflammatory and antioxidant properties of Zinc have long been documented. [Wessels, I. Zinc as a Gatekeeper of Immune Function. Nutrients. 2017 Dec; 9(12):1286. Doi: 10.3390/ni9121286. PMID: 29186856],
2. Vitamin D3 (cholecalciferol) or oral Vitamin D2 (ergocalciferol) is converted to 25(OH)D in the liver and then to the hormonal metabolite, 1,25(OH)2D (calcitriol), in the kidneys or other organs as needed. The Roles of 25(OH)D in immunomodulation, lung, muscle and cardiovascular function, and infectious disease prevention [Gombart A.F., et al. A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients. 2020; 12:236. doi: 10.3390/nu12010236; Schwalfenberg G.K. A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency. Mol. Nutr. Food Res. 2011; 55:96–108. doi: 10.1002/mnfr.201000174; Kast J.I., et al. Respiratory syncytial virus infection influences tight junction integrity. Clin. Exp. Immunol. 2017; 190:351–359. doi: 10.1111/cei.13042; Chen Y., et al. Epidemiological features and time-series analysis of influenza incidence in urban and rural areas of Shenyang, China, 2010–2018. Epidemiol. Infect. 2020;148: e29. doi: 10.1017/S0950268820000151]. Induce cathelicidins and defensins that lower viral replication rates; reduce apoptosis of pneumocytes and stimulate surfactant synthesis in these cells to prevent severe lung injuries (ARDS) [Adams J.S., et al. Vitamin D-directed rheostatic regulation of monocyte antibacterial responses. J. Immunol. 2009; 182:4289–4295. doi: 10.4049/jimmunol.0803736; Laaksi I. Vitamin D and respiratory infection in adults. Proc. Nutr. Soc. 2012; 71:90–97. doi: 10.1017/S0029665111003351]; reduce concentrations of pro-inflammatory cytokines that injures the lining of the lungs, as well as increase the concentrations of anti-inflammatory cytokine. [Huang C., et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 doi: 10.1016/S0140-6736(20)30183-5; Cantorna M.T. Mechanisms underlying the effect of vitamin D on the immune system. Proc. Nutr. Soc. 2010; 69:286–289. doi: 10.1017/S0029665110001722].
First Saturday of February 2022.
Milton L. Pozo, MD., FACP.
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SARS-CoV-2 DISEASE, THE TRIUMPH OF PROPHYLAXIS & TREATMENT
According to the CDC, the lineage of SARS-CoV-2 is 1. WUHAN, 2. ALPHA (B.1.1.7, Q.1-Q.8), 3. BETA (B.1.351, B.1.351.2, B.1.351.3), 4. GAMMA (P.1, P.1.1, P.1.2), 5. EPSILON (B.1.427 and B.1.429), 6. ETA (B.1.525), 7. DELTA (B.1.617, B.1.617.2, B.1.617.3), 8. IOTA (B.1.526), 9. KAPPA (B.1.617.1), 10. B.1.617.3, 11. MU (B.1.621, B.1.621.1), 12. ZETA (P.2) and 13. Omicron (B.1.1529) However, it is acknowledged that there is an increasing number of sub-lineages that are associated with Alpha, Delta, and Gamma. What is the cause of this explosion of mutations, never seen before?
Further, in Vaccine effectiveness from real-world studies, we are told that Healthcare workers, first responders, and other essential and frontline workers had an effectiveness rate of 66% to SARS-CoV-2 from Pfizer-BioNTech, Moderna, or Janssen in the USA. Moreover, they now indicate that "More data are needed to know if Omicron infections, and especially reinfections and breakthrough infections in people who are fully vaccinated, cause more severe illness or death than infection with other variants". Yet, Florida reported 1,192 deaths this week, [1/28/22] the highest death rate since October’s 2021 Delta wave and nearly twice as many deaths as the previous week. Thus, the headlines "Omicron drives US deaths higher than in Fall’s Delta wave."
In a Strange Way Uttar Pradesh, India VALIDATED the PROPHYLAXIS PROTOCOL. In an aggressive house-to-house test and treat program they were able to drop a staggering 97.1%. of new COVID-19 infections in 5 weeks. By July 2, 2021, three weeks later, cases were down a full 99%.
By August 25, 2021, the media noted that Uttar Pradesh had 5% of the population vaccinated. The government started a vaccination campaign and by October 30, 2021, 20% of adults were fully vaccinated and about 32 million got their second dose. Effectively, by December 23, 2021, over 66.4 million people in Uttar Pradesh are fully vaccinated.
Yet, by January 11, 2022, the Times of India reported that Uttar Pradesh had 33,946 active COVID -19 cases up 28 times in 10 days.
So, what happened? Why this surge when they were able to reduce the infection rate to 99%
Was there a Vaccination Priming or lack of Prevention with Zinc, Vitamins C and D3, or both?
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Neurology
United States
Stop being victims! You don’t have to get cancer! Mediterranean diet! Vitamin D3 and Zinc with time release Vitamin C!
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Immunology and Allergy
United States
sleep apnea the most common cause either as primary disease process or secodary process commonly upper airway syndromes but also gerd check vitD ferritin and zinc as well as T4/TSH home sleep study is easy to doo to confirm
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General Medicine
Romania
After a period of regular testing forced on us in order to be allowed to see patients and work on the hospital, I finally had omicron in January of last year, I’m not “vaccinated” for covid (but vaccinated for almost everything else under the sun, including yellow fever and TB!, you know, the true vaccines!), I was tested three times a week in order to be allowed by “the regime” to work in the hospital. My covid omicron lasted three days with mild headaches and myalgia, chills in the evening and fever up to 39C, which I didn’t lower because the benefits of the fever killing the viruses was a natural way of defense which I wanted, I also had cough for one week. That was all! Before and after that period I never avoided any family members who wanted to socialize, I kissed and hugged my nephews and nieces, never wore the mask only where it was compulsory (hospital and stores).
I even went to do very stupid things (like shaking hands with confirmed covid people, staying in the same room for more than 15 minutes, no mask) wanting to get a second covid, because the regime would stop testing me for another six months after an eventual new covid diagnosis. Wasn’t lucky, I didn’t get covid no matter how hard I’ve tried, they kept testing me until last November when the regime eventually stopped that nonsense. My natural immunity for this pest must be for life, and I didn’t genetically modified my immune system with the mRNA kindly offered and promoted by politicians, media and the great big pharma.The truth is that I did and do Dr Zelenko’s protocol (zinc, vitamin D and Quercetin) I’d use ivermectin instead of quercetin as it would be a better ionophore for zinc but is forbidden even to talk about it, forget about prescribing it under our regime.Right now I’m not wearing mask while I consult patients, I’m taking the Dr Zelenko protocol, prevention treatment because during this period more than half of my patients have colds and flus(confirmed by rapid tests).
“Primum non nocere”
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New data in @JournalSpectrum show that exposure to sublethal concentrations of zinc over several day...
New data in @JournalSpectrum show that exposure to sublethal concentrations of zinc over several days increases the… https://t.co/gpeF2gQh2xMarch 02,2023
Supplementation of Some Micronutrients May Improve CVD Outcomes
THURSDAY, Dec. 8, 2022 (HealthDay News) -- Supplementation of some micronutrients may reduce cardiovascular disease (CVD) outcomes, according to a review published in the Dec. 13 issue of the Journal of the American College of Cardiology.
Peng An, Ph.D., from China Agricultural University in Beijing, and colleagues conducted a systematic review and meta-analysis of randomized controlled intervention trials of micronutrients on CVD risk factors and clinical events. Data were included from 884 trials evaluating 27 types of micronutrients among 883,627 participants.
The researchers found moderate- to high-quality evidence that supplementation with n-3 fatty acid, n-6 fatty acid, L-arginine, L-citrulline, folic acid, vitamin D, magnesium, zinc, α-lipoic acid, coenzyme Q10, melatonin, catechin, curcumin, flavanol, genistein, and quercetin reduced CVD risk factors. Supplementation with n-3 fatty acids reduced CVD mortality, myocardial infarction, and coronary heart disease events (relative risks, 0.93, 0.85, and 0.86, respectively). Supplementation with folic acid reduced stroke risk, while all-cause mortality events were reduced with coenzyme Q10 supplementation (relative risks, 0.84 and 0.68, respectively). Increased all-cause mortality, CVD mortality events, and stroke risk were seen with β-carotene supplementation (relative risks, 1.10, 1.12, and 1.09, respectively).
"The comprehensive evidence map presented here highlights the importance of micronutrient diversity and the balance of benefits and risks in the design of whole food-based dietary patterns to promote cardiometabolic health, which may require cultural adaptations to apply globally," the authors write.
Two authors disclosed financial ties to pharmaceutical and nutrition companies.
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Nutritional Supplements May Have Role in Hair Loss Treatment
THURSDAY, Dec. 1, 2022 (HealthDay News) -- There may be a potential role for nutritional supplements in the treatment of hair loss, according to a review published online Nov. 30 in JAMA Dermatology.
Lara Drake, from the Tufts University School of Medicine in Boston, and colleagues conducted a systematic review to examine and compile the findings of all dietary and nutritional interventions for treatment of hair loss in individuals without known baseline nutritional deficiency. Data were included from 30 articles: 17 randomized clinical trials (RCTs), 11 clinical studies (non-RCTs), and two case series studies.
The researchers found a potential benefit of Viviscal, Nourkrin, Nutrafol, Lambdapil, Pantogar, capsaicin and isoflavone, omegas 3 and 6 with antioxidants, apple nutraceutical, total glucosides of paeony and compound glycyrrhizin tablets, zinc, tocotrienol, and pumpkin seed oil in studies of nutritional interventions with the highest-quality evidence. Low-quality evidence for disease course improvement was seen for kimchi and cheonggukjang, vitamin D3, and Forti5. For all therapies evaluated, adverse effects were rare and mild.
"Some patients with hair loss may benefit from nutritional supplementation, and shared decision-making with dermatologists should be encouraged to review risks and benefits of each treatment," the authors write.
Two authors disclosed financial ties to the pharmaceutical industry.
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